Maurizio Sarri's men can no longer be caught by their closest challengers, Inter, in their two remaining fixtures this season.
Cristiano Ronaldo opened the scoring for the Bianconeri, finishing off a set-piece routine from the edge of the area.
Federico Bernardeschi added a second goal halfway through the second half before Sampdoria were reduced to 10 men following Morten Thorsby's sending off.
Ronaldo could've rounded off the scoring with a late penalty, but his effort crashed back off the crossbar.
Sarri has continued Juve's Scudetto streak in his first season in charge, adding a ninth consecutive Serie A title to the previous eight won between Antonio Conte and Massimiliano Allegri.
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